ENVIRONMENT AND ANIMAL SOURCES OF LEPROSY TRANSMISSION: LITERATURE REVIEW
DOI:
https://doi.org/10.35730/jk.v12i0.621Abstract
Efforts in the prevention and treatment of leprosy have improved, but until now leprosy is still difficult to be eliminated so that it is still a problem in the world of health. The incidence of new leprosy patients has not decreased, although the prevalence of leprosy continues to decline through the WHO program, namely multi-drug therapy (MTD). Several new cases have been found without involving any contact history. It is suspected that there is a contribution from sources other than humans, namely non-humans such as animals and the environment. This article discusses the sources of transmission of M. leprae from animals and the environment. Research using literature review is limited to the last 10 years by reviewing 8 relevant journals about sources of transmission and modes of transmission from the environment and non-humans in Mycobacterium leprae. This article has been filtered from 35 articles sourced from the Pubmed, NCBI, Plos One and Science Direct databases, then there are 23 articles that are not relevant, so 12 articles were reviewed. Based on the results of a review article that the source of leprosy transmission came from animals, it was found in Rhodnius prolixus, Dasypus novemcinctus and red squirrels, while chimpanzees and monkeys were not the source of M. leprae transmission. In the environment where M. leprae is commonly found in the soil.
ÂReferences
P. Saumya and V. Shyam, “The menace of dermatophytosis in India: The evidence that we need,†Indian J. Dermatol. Venereol. Leprol., vol. 84, no. 1, pp. 6–15, 2018, doi: 10.4103/ijdvl.IJDVL.
S. Mathis, A. Soulages, G. Le Masson, and J. M. Vallat, “Epidemics and outbreaks of peripheral nervous system disorders: I. infectious and immune-mediated causes,†J. Neurol., vol. 268, no. 3, pp. 879–890, 2021, doi: 10.1007/s00415-020-10215-9.
L. J. Lowenstine, R. McManamon, and K. A. Terio, Apes. Elsevier Inc., 2018.
A. Da Silva Neumann et al., “Experimental infection of Rhodnius prolixus (hemiptera, triatominae) with Mycobacterium leprae indicates potential for leprosy transmission,†PLoS One, vol. 11, no. 5, pp. 1–14, 2016, doi: 10.1371/journal.pone.0156037.
Da Silva, M. B., Portela, J. M., Li, W., Jackson, M., Gonzalez-Juarrero, M., Hidalgo, A. S., Belisle, J. T., Bouth, R. C., Gobbo, A. R., Barreto, J. G., Minervino, A., Cole, S. T., Avanzi, C., Busso, P., Frade, M., Geluk, A., Salgado, C. G., & Spencer, J. S. (2018). Evidence of zoonotic leprosy in Pará, Brazilian Amazon, and risks associated with human contact or consumption of armadillos. PLoS neglected tropical diseases, 12(6), e0006532. https://doi.org/10.1371/journal.pntd.0006532
Ploemacher, T., Faber, W. R., Menke, H., Rutten, V., & Pieters, T. (2020). Reservoirs and transmission routes of leprosy; A systematic review. PLoS neglected tropical diseases, 14(4), e0008276. https://doi.org/10.1371/journal.pntd.0008276).
Vanzi, C., Del-Pozo, J., Benjak, A., Stevenson, K., Simpson, V. R., Busso, P., McLuckie, J., Loiseau, C., Lawton, C., Schoening, J., Shaw, D. J., Piton, J., Vera-Cabrera, L., Velarde-Felix, J. S., McDermott, F., Gordon, S. V., Cole, S. T., & Meredith, A. L. (2016). Red squirrels in the British Isles are infected with leprosy bacilli. Science (New York, N.Y.), 354(6313), 744–747. https://doi.org/10.1126/science.aah3783)
Honap TP, Pfister LA, Housman G, Mills S, Tarara RP, et al. (2018) Mycobacterium leprae genomes from naturally infected nonhuman primates. PLOS Neglected Tropical Diseases 12(1): e0006190. https://doi.org/10.1371/journal.pntd.0006190
X. Chen and T.-J. Shui, “The state of the leprosy epidemic in Yunnan, China 2011–2020: A spatial and spatiotemporal analysis, highlighting areas for intervention,†PLoS Negl. Trop. Dis., vol. 15, no. 10, p. e0009783, 2021, doi: 10.1371/journal.pntd.0009783.
R. S. Gnimavo et al., “Trends of the leprosy control indicators in Benin from 2006 to 2018,†BMC Public Health, vol. 20, no. 1, pp. 1–11, 2020, doi: 10.1186/s12889-020-09341-w.
Tió-Coma, M., Wijnands, T., Pierneef, L. et al. Detection of Mycobacterium leprae DNA in soil: multiple needles in the haystack. Sci Rep 9, 3165 (2019). https://doi.org/10.1038/s41598-019-39746-6
Ravindra P. Turankar, Mallika Lavania, Mradula Singh, Krovvidi S.R. Siva Sai, Rupendra S Jadhav, Dynamics of Mycobacterium leprae transmission in environmental context: Deciphering the role of environment as a potential reservoir, Infection, Genetics and Evolution,Volume 12, Issue 1,2012, Pages 121-126,ISSN 1567-1348, https://doi.org/10.1016/j.meegid.2011.10.023.)